Synonyms: lipoxin B4
Compound class:
Metabolite
Comment: Lipoxin B4 (LXB4) is a member of the lipoxin family. In inflammation it acts as a proresolving mediator [8].
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Immunopharmacology Comments |
Lipoxin B4 (LXB4) promotes resolution of inflammation. It is produced by mucosal tissues. In the lung its activity decreases allergic and asthmatic inflammatory responses [4]. In the adaptive immune system, Kim et al. (2018) have demonstrated that LXB4 induces increased COX-2 expression which in turn elevates memory B cell numbers and their production of IgG antibodies [5]. The authors conclude that LXB4 could therefore be utilised as a vaccine adjuvant. |