Ligand id: 5675

Name: canertinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 88.61
Molecular weight 485.16
XLogP 3.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
A study by Trinks et al. (2011) shows that canertinib has inhibitory effects on kinases other than the EGFRs, including kinases which are involved in T-cell signaling [7]. This non-EGFR activity can induce caspase-mediated cell death of Jurkat cells, and indicates some potential for canertinib as a therapy for human T-cell leukemia [3].