CXCL17

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Ligands
CXCL17 (Human)

GtoPdb Ligand ID: 6479

Synonyms: C-X-C motif chemokine 17 | dendritic cell and monocyte chemokine-like protein

Compound class: Endogenous peptide in human, mouse or rat

Comment: CXCL17 is a CXC family chemokine reported in human and rat, with a mucosal expression pattern.

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
CXCL17 is a chemoattractant for dendritic cells and monocytes, and it potently attracts lung macrophages [1] and has broad antimicrobial activity [2]. Expression has been detected in some types of cancer cells, where its angiogenic action may be relevant [3]. Evidence suggests it may be an agonist of the orphan GPCR, GPR35 [4].

Immunopharmacology Comments

CXCL17 is a chemoattractant for dendritic cells and monocytes, and it potently attracts lung macrophages [1] and has broad antimicrobial activity [2]. Expression has been detected in some types of cancer cells, where its angiogenic action may be relevant [3]. Evidence suggests it may be an agonist of the orphan GPCR, GPR35 [4].