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Compound class: Endogenous peptide in human, mouse or rat
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
|Gal-1 is a mammalian lectin that modulates T cell function and apoptosis. Gal-1 (expressed by stromal cells) is also required for the development of B cells in the bone marrow  and contributes to the induction of B cells regulatory function .|
|Graft versus host disease||Gal-1 reduces host alloreactivity and suppresses the graft versus host immune response in animal GvHD models, leading to increased survival.||2|