galectin-1   Click here for help

GtoPdb Ligand ID: 6603

Synonyms: GBP
Immunopharmacology Ligand
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
Species: Human
Immunopharmacology Comments
Gal-1 is a mammalian lectin that modulates T cell function and apoptosis. Gal-1 (expressed by stromal cells) is also required for the development of B cells in the bone marrow [3] and contributes to the induction of B cells regulatory function [1].
Immunopharmacology Disease
Disease X-Refs Comment References
Graft versus host disease Gal-1 reduces host alloreactivity and suppresses the graft versus host immune response in animal GvHD models, leading to increased survival. 2