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Compound class: Endogenous peptide in human, mouse or rat
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
1. Alhabbab R, Blair P, Smyth LA, Ratnasothy K, Peng Q, Moreau A, Lechler R, Elgueta R, Lombardi G. (2018)
Galectin-1 is required for the regulatory function of B cells.
Sci Rep, 8 (1): 2725. [PMID:29426942]
2. Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, Hoffmann D, Emmanouilides CE, Territo MC, Baldwin GC. (2003)
Amelioration of graft versus host disease by galectin-1.
Clin. Immunol., 109 (3): 295-307. [PMID:14697744]
3. Espeli M, Mancini SJ, Breton C, Poirier F, Schiff C. (2009)
Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions.
Blood, 113 (23): 5878-86. [PMID:19329777]
4. Walzel H, Schulz U, Neels P, Brock J. (1999)
Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.
Immunol. Lett., 67 (3): 193-202. [PMID:10369126]