galectin-1   Click here for help

GtoPdb Ligand ID: 6603

Synonyms: GBP
Immunopharmacology Ligand
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
Species: Human
1. Alhabbab R, Blair P, Smyth LA, Ratnasothy K, Peng Q, Moreau A, Lechler R, Elgueta R, Lombardi G. (2018)
Galectin-1 is required for the regulatory function of B cells.
Sci Rep, 8 (1): 2725. [PMID:29426942]
2. Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, Hoffmann D, Emmanouilides CE, Territo MC, Baldwin GC. (2003)
Amelioration of graft versus host disease by galectin-1.
Clin Immunol, 109 (3): 295-307. [PMID:14697744]
3. Espeli M, Mancini SJ, Breton C, Poirier F, Schiff C. (2009)
Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions.
Blood, 113 (23): 5878-86. [PMID:19329777]
4. Walzel H, Schulz U, Neels P, Brock J. (1999)
Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.
Immunol Lett, 67 (3): 193-202. [PMID:10369126]