loratadine   Click here for help

GtoPdb Ligand ID: 7216

Synonyms: Claritin® | SCH-29851
Approved drug Immunopharmacology Ligand
loratadine is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Loratidine is an antihistamine; peripheral H1 receptor antagonist; antiallergic agent.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 42.43
Molecular weight 382.14
XLogP 3.82
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
Isomeric SMILES CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
InChI InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI Key JCCNYMKQOSZNPW-UHFFFAOYSA-N
Immunopharmacology Comments
Loratadine is a commonly used anti-histamine drug, often available OTC in anti-allergy and hayfever medications.
Immunopharmacology Disease
Disease X-Refs Comment References
Allergic rhinitis Disease Ontology: DOID:4481
Antihistamine approved for allergic rhinitis.
Chronic idiopathic urticaria Antihistamine approved for CIU.