CCL24   Click here for help

GtoPdb Ligand ID: 775

Synonyms: eotaxin-2
Immunopharmacology Ligand
Comment: CCL24 is a CC family chemokine.
Species: Human
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Immunopharmacology Comments
CCL24 is a ligand for the chemokine receptor CCR3. It is a chemoattractant for eosinophils [6], resting T lymphocytes and neutrophils.
An anti-CCL24 monoclonal antibody known as CM101 is being developed by ChemomAb as a potential first-in-class therapy for inflammatory and fibrotic diseases [2]. CM101 has been granted FDA orphan drug designation for the treatment of primary sclerosing cholangitis [1].
Immunopharmacology Disease
Disease X-Refs Comment References
Aspirin exacerbated respiratory diseases Elevated CCL24 levels have been detected in patients with AERD 4