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Synonyms: eotaxin-2
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CCL24 is a CC family chemokine.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| CCL24 is a ligand for the chemokine receptor CCR3. It is a chemoattractant for eosinophils [6], resting T lymphocytes and neutrophils. An anti-CCL24 monoclonal antibody known as CM101 is being developed by ChemomAb as a potential first-in-class therapy for inflammatory and fibrotic diseases [2]. CM101 has been granted FDA orphan drug designation for the treatment of primary sclerosing cholangitis [1]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Aspirin exacerbated respiratory diseases | Elevated CCL24 levels have been detected in patients with AERD | 4 | |
