spebrutinib

Ligand id: 7837

Name: spebrutinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 97.4
Molecular weight 423.17
XLogP 3.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Completed Phase 2 clinical evaluation in RA (see NCT01975610).
B-cell lymphoma Disease Ontology: DOID:707
Phase 1 clinical candidate for B cell malignancies (see NCT01766583).
B-cell chronic lymphocytic leukemia OMIM: 151400
Orphanet: ORPHA67038
Phase 1 clinical candidate for B cell malignancies (see NCT01732861).