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Synonyms: TARC | thymus- and activation-regulated chemokine
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL17 is a CC family cytokine.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|CCL17 is constitutively expressed in thymus. It acts via the G protein-coupled chemokine receptor CCR4 and induces T cell chemotaxis.
CCL17 has been identified as a novel molecular target whose blockade offers clinical potential as a mechanism to treat both the pain and pathology associated with osteoarthritis . Glaxo Smith Kline have a CCL17 inhibitor (GSK3858279) in their development pipeline which has been advanced to Phase 1 evaluation (see NCT03485365), although the nature of this agent has not been formally disclosed (July 2019).
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