cabiralizumab   Click here for help

GtoPdb Ligand ID: 9107

Synonyms: BMS-986227 | FPA-008 | FPA008
Immunopharmacology Ligand
Compound class: Antibody
Comment: Cabiralizumab is an investigational humanized monoclonal antibody targeting the receptor tyrosine kinase, CSF1R (Fms). It is being investigated for its potential anti-cancer activity.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Protein BLAST analysis reveals 100% matches with peptides claimed in patent US20110274683 [1]
Click here for help
Immunopharmacology Comments
Anti-CSF1R antibodies prevent binding of the receptor's endogenous ligand CSF1 (or M-CSF) and this action reduces monocyte infiltration into tumours and inhibits the accumulation of tumour-associated macrophages (TAMs).
Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Phase 1 in RA terminated and development discontinued.