Synonyms: Agamree® | VBP-15 | VBP15
vamorolone is an approved drug (FDA & EMA (2023))
Compound class:
Synthetic organic
Comment: Vamorolone (VBP15) is a novel, oral non-hormonal steroid modulator, that was investigated in Duchenne muscular dystrophy. It is a multi-functional drug that exhibits anti-inflammatory, membrane stabilisation, and mineralocorticoid receptor antagonist activities. Vamorolone was proposed as a potential replacement for the corticosteroids that are currently used in DMD, as it appears to cause fewer of the common corticosteroid adverse effects [4].
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Immunopharmacology Comments |
VBP15 selectively engages the GR, exerting anti-inflammatory and membrane stabilising effects [1]. |