compound 9 [PMID: 26006010]

Ligand id: 9761

Name: compound 9 [PMID: 26006010]

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 135.42
Molecular weight 610.28
XLogP 4.03
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
Selective BTK inhibitors are being investigated for clinical potential in autoimmune diseases, based on evidence of activity in rodent models of inflammation, including in collagen-induced arthritis [2,4]. BTK appears to play a significant role in neutrophil recruitment to tissues, therefore BTK inhibition should decrease neutrophil numbers in tissues and thereby reduce inflammation.