compound 7f [PMID: 29191554]

Ligand id: 9794

Name: compound 7f [PMID: 29191554]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 11
Topological polar surface area 155.58
Molecular weight 593.2
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
Chymase in mast cell granules is strongly implicated in inflammation. Chymase inhibitors are under investigation for their anti-inflammatory potential in human diseases such as bronchial asthma, chronic obstructive pulmonary disease, urticaria, atopic dermatitis, allergic conjunctivitis, rhinitis, rheumatoid arthritis, food allergies and colitis.