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Synonyms: compound 20 [PMID: 18835163] | MK0873
Compound class: Synthetic organic
Comment: MK-0873 is an optimized investigational PDE4 inhibitor with favourable in vitro and in vivo profiles that support clinical development .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|MK-0873 is a PDE4 inhibitor that was a clinical candidate for inflammatory diseases. It inhibits LPS-induced production of TNF-α in human whole blood assays. No clinical trial results appear to have been published in peer reviewed literature.
|Completed Phase 2 trial for plaque psoriasis- see NCT01140061
|Completed Phase 2 trial for RA- see NCT00132769