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Compound class: Synthetic organic
Comment: RP-101075 is an active metabolite of ozanimod . It demonstrates similar in vitro specificity for S1P receptors as ozanimod and has a comparable pharmacodynamic profile in vivo.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|The parent compound, ozanimod, is being investigated for its antiinflammatory action in autoimmune conditions. Both ozanimod and RP-101075 reduce chronic inflammation and alleviate kidney pathology in a mouse model of systemic lupus erythematosus (SLE), findings that suggest that ozanimod may offer clinical benefit as a SLE therapeutic .|