Ligand id: 9938

Name: pCXCL8-1aa

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Immunopharmacology Comments
pCXCL8-1aa reduces disease severity and serum levels of proinflammatory TNFα in a murine antigen-induced arthritis model, an effect that is mediated by reduced leukocyte activation and infiltration at arthritic sites. Disruption of the cytokine-GAG-cytokine receptor axis is considered as a novel mechanism to be expolited for the development of new classes of anti-inflammatory agents [1].