compound 15 [PMID: 29852070]

Ligand id: 9997

Name: compound 15 [PMID: 29852070]

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 133.06
Molecular weight 433.11
XLogP 1.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
PI3Kγ is a class I PI3K that is predominantly expressed in leukocytes and which is a long-standing target of drug discovery for inflammatory pathologies that are characterised by a high influx of inflammatory effector cells. Isoform selectivity is essential for successful (safe) drug development because PI3Kα is known to affect glucose and insulin signalling [1].