halofuginone   Click here for help

GtoPdb Ligand ID: 10153

PDB Ligand Antimalarial Ligand
Compound class: Synthetic organic
Comment: Halofuginone is a synthetic derivative of febrifugine, a quinazolinone alkaloid first isolated from the roots of the blue evergreen hydrangea (D. febrifuga) and used as an antimalarial remedy in traditional Chinese medicine. The INN record for halofuginone indicates that it is a racemic mixture. We show the chemical structure without stereochemistry to represent the mixture.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 84.22
Molecular weight 413.01
XLogP 2.81
No. Lipinski's rules broken 0
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Canonical SMILES O=C(Cn1cnc2c(c1=O)cc(c(c2)Br)Cl)CC1NCCCC1O
Isomeric SMILES O=C(Cn1cnc2c(c1=O)cc(c(c2)Br)Cl)CC1NCCCC1O
InChI InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2
Guide to Malaria Pharmacology Comments
The use of halofuginone as an antimalarial medicine is precluded by intolerable side-effects and it is used instead as an antiprotozoal agent in veterinary medicine.

Potential Target/Mechanism Of Action: halofuginone activates the amino acid response pathway by direct inhibition of the PfcPRS activity of glutamyl-prolyl tRNA synthetase (EPRS) [3].