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Synonyms: Quinaglute® | Quinidex® | quinidine hydrochloride
quinidine is an approved drug (FDA (1950))
Compound class: Natural product or derivative
Comment: Quinidine is a stereoisomer of quinine. It acts as a class I antiarrhythmic agent, blocking the fast inward sodium current (INa).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: quinidine
|Guide to Malaria Pharmacology Comments|
|Quinidine is an effective antimalarial treatment for P. falciparum infections . The United States Centers for Disease Control and Prevention (CDC) guidelines, recommend intravenous quinidine gluconate treatment in cases of severe malaria. The manufacture of this drug has been discontinued by the manufacturer but product distribution continued until labelled expiry of March 2019.|