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Compound class: Synthetic organic
Comment: Inhibitor 1 inhibits the ORAI1 protein component of the CRAC channel . The chemical structure represents a novel ORAI1-specific chemotype that is suitable for the development of more refined CRAC channel inhibitors.
1. Zhang HZ, Xu XL, Chen HY, Ali S, Wang D, Yu JW, Xu T, Nan FJ. (2015)
Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.
Acta Pharmacol. Sin., 36 (9): 1137-44. [PMID:26256403]