RasGRP activator 1   Click here for help

GtoPdb Ligand ID: 10066

Synonyms: compound 1 [PMID: 24794745]
Compound class: Synthetic organic
Comment: This is a DAG-indololactone class compound that was developed as an activator of RAS guanyl releasing proteins (RasGRP) that can discriminate between RasGRPs and protein kinase C (PKC) isoforms [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 77.76
Molecular weight 413.22
XLogP 4.58
No. Lipinski's rules broken 0
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Canonical SMILES CCCC(C(=O)OCC1(CO)OC(=O)C(=Cc2cn(c3c2cccc3)C)C1)CCC
Isomeric SMILES CCCC(C(=O)OCC1(CO)OC(=O)/C(=C/c2cn(c3c2cccc3)C)/C1)CCC
InChI InChI=1S/C24H31NO5/c1-4-8-17(9-5-2)22(27)29-16-24(15-26)13-18(23(28)30-24)12-19-14-25(3)21-11-7-6-10-20(19)21/h6-7,10-12,14,17,26H,4-5,8-9,13,15-16H2,1-3H3/b18-12+
1. Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE et al.. (2014)
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Bioorg Med Chem, 22 (12): 3123-40. [PMID:24794745]