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Synonyms: Fub-mdmb | Mdmb-bz-F | Mdmb-fub
Compound class: Synthetic organic
Comment: MDMB-Fubinaca is an extremely potent, synthetic cannabinoid CB1/CB2 receptor agonist . Cryo-EM of the ligand-receptor complex shows that it locks the CB1 receptor in an active conformation .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Kumar, KK, Shalev-Benami M, Robertson MJ, Malhorta SV, Kobilka BK, Skiniotis G. (2019)
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, In Press/Online now. DOI: 10.1016/j.cell.2018.11.040
2. Schoeder CT, Hess C, Madea B, Meiler J, Müller CE. (2018)
Pharmacological evaluation of new constituents of "Spice": synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds.
Forensic Toxicol, 36 (2): 385-403. [PMID:29963207]