NE 52-QQ57   Click here for help

GtoPdb Ligand ID: 10206

Synonyms: example 35 [WO2012131633A1] [1] | GPR4 antagonist 13 [4] | NE52-QQ57
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: NE 52-QQ57 is an orally bioavailable, selective antagonist of the class A orphan GPCR, GPR4 [4]. It is one of the chemical structures claimed in Novartis' patent WO2012131633A1 [1].
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 81.14
Molecular weight 416.23
XLogP 4.24
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CCc1nn2c(c1Cc1ccc(cc1)c1nnc(o1)C1CCNCC1)nc(cc2C)C
Isomeric SMILES CCc1nn2c(c1Cc1ccc(cc1)c1nnc(o1)C1CCNCC1)nc(cc2C)C
InChI InChI=1S/C24H28N6O/c1-4-21-20(22-26-15(2)13-16(3)30(22)29-21)14-17-5-7-18(8-6-17)23-27-28-24(31-23)19-9-11-25-12-10-19/h5-8,13,19,25H,4,9-12,14H2,1-3H3
InChI Key HXPQWNPLNIEJOW-UHFFFAOYSA-N
References
1. Du Z, Leleti RR, Liu Y, Miltz W, Oberhauser B, Vaupel A, Velcicky J, Weigand K. (2012)
Pyrazolo pyrimidine derivatives.
Patent number: WO2012131633A1. Assignee: Novartis Ag. Priority date: 01/04/2011. Publication date: 04/10/2012.
2. Miltz W, Velcicky J, Dawson J, Littlewood-Evans A, Ludwig MG, Seuwen K, Feifel R, Oberhauser B, Meyer A, Gabriel D et al.. (2017)
Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.
Bioorg Med Chem, 25 (16): 4512-4525. [PMID:28689977]
3. Sanderlin EJ, Marie M, Velcicky J, Loetscher P, Yang LV. (2019)
Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.
BioRxiv, pre-print of new results. DOI: 10.1101/533174
4. Velcicky J, Miltz W, Oberhauser B, Orain D, Vaupel A, Weigand K, Dawson King J, Littlewood-Evans A, Nash M, Feifel R et al.. (2017)
Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.
J Med Chem, 60 (9): 3672-3683. [PMID:28445047]