- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: compound 20dd [PMID: 28406646]
Compound class: Synthetic organic
Comment: SLC4101431 is a sphihgosine kinase inhibitor with ~100-fold selectivity for the SK2 isozyme compared to SK1 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Childress ES, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. (2017)
Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.
J Med Chem, 60 (9): 3933-3957. [PMID:28406646]