[d-Tyr-14C]TAK-448   Click here for help

GtoPdb Ligand ID: 10223

 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
Comment: The synthetic peptide TAK-448 is a kisspeptin receptor agonist [2]. [d-Tyr-14C]TAK-448 is a radiolabelled probe analogue that was designed for pharmacokinetic analysis in preclinical animal studies [1].
1. Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S. (2019)
Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study.
Xenobiotica, 49 (7): 833-839. [PMID:30044673]
2. Nishizawa N, Takatsu Y, Kumano S, Kiba A, Ban J, Tsutsumi S, Matsui H, Matsumoto SI, Yamaguchi M, Ikeda Y et al.. (2016)
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.
J Med Chem, 59 (19): 8804-8811. [PMID:27589480]