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Synonyms: compound 30 [PMID: 26267383] | Nag 30
Compound class: Synthetic organic
Comment: Non-peptide Orexin receptor 2 agonist.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T et al.. (2017)
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Proc Natl Acad Sci USA, 114 (22): 5731-5736. [PMID:28507129]
2. Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M et al.. (2015)
Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.
J Med Chem, 58 (20): 7931-7. [PMID:26267383]
3. Rinne MK, Leino TO, Turku A, Turunen PM, Steynen Y, Xhaard H, Wallén EAA, Kukkonen JP. (2018)
Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26.
Eur J Pharmacol, 837: 137-144. [PMID:30194937]