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Compound class: Synthetic organic
Comment: ANTA XV is a potent, orally bioavailable small-molecule SMO antagonist that was designed for antitumour potential [1-2].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bao X, Peng Y, Lu X, Yang J, Zhao W, Tan W, Dong X. (2016)
Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors.
Bioorg. Med. Chem. Lett., 26 (13): 3048-3051. [PMID:27180012]
2. Miller-Moslin K, Peukert S, Jain RK, McEwan MA, Karki R, Llamas L, Yusuff N, He F, Li Y, Sun Y et al.. (2009)
1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
J. Med. Chem., 52 (13): 3954-68. [PMID:19469545]