Synonyms: example 2A [WO2010129379] | MK7145
Compound class:
Synthetic organic
Comment: MK-7145 is a Kir1.1 (ROMK) inhibitor that was designed as a novel diuretic [3]. The chemical structure is claimed as example 2A in patent WO2010129379 [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Aretz CD, Vadukoot AK, Hopkins CR. (2019)
Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics. J Med Chem, 62 (19): 8682-8694. [PMID:31034224] |
2. Pasternak A, Shahripour A, Tang H, Teumelsan NH, Yang L, Zhu Y, Walsh SP. (2010)
Inhibitors of the renal outer medullary potassium channel. Patent number: WO2010129379A1. Assignee: Merck Sharp & Dohme Corp. Priority date: 06/05/2009. Publication date: 11/11/2010. |
3. Tang H, Zhu Y, Teumelsan N, Walsh SP, Shahripour A, Priest BT, Swensen AM, Felix JP, Brochu RM, Bailey T et al.. (2016)
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure. ACS Med Chem Lett, 7 (7): 697-701. [PMID:27437080] |