Compound class:
Synthetic organic
Comment: Naphthoquine is a 4-aminoquinoline antimalarial compound.
The marketed formulations contain naphthoquine phosphate (PubChem CID 9851774). The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
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References |
1. Combrinck JM, Mabotha TE, Ncokazi KK, Ambele MA, Taylor D, Smith PJ, Hoppe HC, Egan TJ. (2013)
Insights into the role of heme in the mechanism of action of antimalarials. ACS Chem Biol, 8 (1): 133-7. [PMID:23043646] |
2. Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler EA, Sinden RE, Leroy D. (2012)
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med, 9 (2): e1001169. [PMID:22363211] |
3. Moore BR, Laman M, Salman S, Batty KT, Page-Sharp M, Hombhanje F, Manning L, Davis TM. (2016)
Naphthoquine: An Emerging Candidate for Artemisinin Combination Therapy. Drugs, 76 (7): 789-804. [PMID:27075024] |
4. (2015)
All chapters. In Guidelines for the Treatment of Malaria (World Health Organization) . [PMID:26020088] [ISBN:9789241549127] |