RA839   Click here for help

GtoPdb Ligand ID: 10487

Synonyms: compound 7 [PMID: 31411465] | RA-839
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: RA839 is a small molecule that noncovalently interacts with KEAP1 and acts as a selective activator of Nrf2-mediated gene transcription [2]. RA839-induced activation of the Nrf2/ARE pathway is reported to produce an anti-rotaviral effect, via inhibition of rotavirus propagation, in vitro [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 95.09
Molecular weight 452.18
XLogP 5.19
No. Lipinski's rules broken 1
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Canonical SMILES OC(=O)C1CCN(C1)c1ccc(c2c1cccc2)NS(=O)(=O)c1c(C)c(C)cc(c1C)C
Isomeric SMILES OC(=O)[C@H]1CCN(C1)c1ccc(c2c1cccc2)NS(=O)(=O)c1c(C)c(C)cc(c1C)C
InChI InChI=1S/C25H28N2O4S/c1-15-13-16(2)18(4)24(17(15)3)32(30,31)26-22-9-10-23(21-8-6-5-7-20(21)22)27-12-11-19(14-27)25(28)29/h5-10,13,19,26H,11-12,14H2,1-4H3,(H,28,29)/t19-/m0/s1
1. Patra U, Mukhopadhyay U, Sarkar R, Mukherjee A, Chawla-Sarkar M. (2019)
RA-839, a selective agonist of Nrf2/ARE pathway, exerts potent anti-rotaviral efficacy in vitro.
Antiviral Res, 161: 53-62. [PMID:30465784]
2. Winkel AF, Engel CK, Margerie D, Kannt A, Szillat H, Glombik H, Kallus C, Ruf S, Güssregen S, Riedel J et al.. (2015)
Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
J Biol Chem, 290 (47): 28446-55. [PMID:26459563]