- Advanced search
- Immuno Portal
- Malaria Portal
Compound class: Synthetic organic
Comment: dTAG-13 is a PROTAC (proteolysis targeting chimera) . It is a hybrid molecule that simultaneously binds FKBP12F36V chimeric proteins and recruits E3 ligase CRL4CRBN to target the defective proteins for destruction via E3 ligase-mediated ubiquitination and proteasomal degradation.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A et al.. (2018)
The dTAG system for immediate and target-specific protein degradation.
Nat Chem Biol, 14 (5): 431-441. [PMID:29581585]