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Synonyms: compound 20o [PMID: 31904232]
Compound class: Synthetic organic
Comment: TG11-77 is reported as a selective, brain-penetrant EP2 receptor antagonist that is suitable for use in models of central nervous system diseases and inflammatory disorders . The hydrochloride salt was used in the majority of testing in . We show the structure for the parent molecule.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Amaradhi R, Banik A, Mohammed S, Patro V, Rojas A, Wang W, Motati DR, Dingledine R, Ganesh T. (2020)
Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.
J Med Chem, 63 (3): 1032-1050. [PMID:31904232]