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Synonyms: compound 43 [PMID: 23844574] | example 5 [WO2013012723A1] | NVP-TNKS-656 | NVPTNKS656 | TNK-S656 | TNKS656
Compound class: Synthetic organic
Comment: NVP‐TNKS656 is a potent and selective inhibitor of the poly(ADP-ribose) polymerase (PARP) tankyrase enzymes, that was designed by Novartis for anti-tumour potential . It is active in vivo.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Cheung AK, Chin DN, Fan J, Miller-Moslin KM, Shultz MD, Smith TD, Tomlinson RC, Toure B-B, Visser MS. (2013)
Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors.
Patent number: WO2013012723A1. Assignee: Novartis Ag, Chen, Zhuoliang. Priority date: 13/07/2011. Publication date: 24/01/2013.
2. Shultz MD, Cheung AK, Kirby CA, Firestone B, Fan J, Chen CH, Chen Z, Chin DN, Dipietro L, Fazal A et al.. (2013)
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
J Med Chem, 56 (16): 6495-511. [PMID:23844574]