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Synonyms: compound 1 [Mathison et al., 2020] | WF47JS03
Compound class: Synthetic organic
Comment: WF-47-JS03 is a RET (REarranged during Transfection) kinase inhibitor that was designed for anti-cancer potential . It is orally bioavailable, but was not well tolerated in mice at higher doses, indicating a narrow therapeutic window.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Mathison CNJ, Chianelli D, Ruckler PV, Nelson J, Roland J, Huang Z, Yang Y, Jiang J, Xie YF, Epple R et al.. (2020)
Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
ACS Med Chem Lett, [Articles ASAP]. DOI: 10.1021/acsmedchemlett.0c00015