Synonyms: CXA-101 | CXA101 | FR-264205 | FR264205 | Zerbaxa® (ceftolozane + tazobactam)
ceftolozane is an approved drug (FDA (2014), EMA (2015))
Compound class:
Synthetic organic
Comment: Ceftolozane is a semi-synthetic, broad-spectrum, fifth-generation cephalosporin antibacterial with activity against certain Gram-negative (e.g. Pseudomonas spp.) and Gram-positive bacteria [6].
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References |
1. Cluck D, Lewis P, Stayer B, Spivey J, Moorman J. (2015)
Ceftolozane-tazobactam: A new-generation cephalosporin. Am J Health Syst Pharm, 72 (24): 2135-46. [PMID:26637512] |
2. Gallagher JC, Satlin MJ, Elabor A, Saraiya N, McCreary EK, Molnar E, El-Beyrouty C, Jones BM, Dixit D, Heil EL et al.. (2018)
Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: A Multicenter Study. Open Forum Infect Dis, 5 (11): ofy280. [PMID:30488041] |
3. Giacobbe DR, Bassetti M, De Rosa FG, Del Bono V, Grossi PA, Menichetti F, Pea F, Rossolini GM, Tumbarello M, Viale P et al.. (2018)
Ceftolozane/tazobactam: place in therapy. Expert Rev Anti Infect Ther, 16 (4): 307-320. [PMID:29493397] |
4. Haidar G, Philips NJ, Shields RK, Snyder D, Cheng S, Potoski BA, Doi Y, Hao B, Press EG, Cooper VS et al.. (2017)
Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: Clinical Effectiveness and Evolution of Resistance. Clin Infect Dis, 65 (1): 110-120. [PMID:29017262] |
5. Moyá B, Zamorano L, Juan C, Ge Y, Oliver A. (2010)
Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. Antimicrob Agents Chemother, 54 (9): 3933-7. [PMID:20547785] |
6. Zhanel GG, Chung P, Adam H, Zelenitsky S, Denisuik A, Schweizer F, Lagacé-Wiens PR, Rubinstein E, Gin AS, Walkty A et al.. (2014)
Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs, 74 (1): 31-51. [PMID:24352909] |