Synonyms: MRX-1 | MRX-I | Youxitai®
contezolid is an approved drug (China (2021))
Compound class:
Synthetic organic
Comment: Contezolid is an oxazolidinone antibacterial against Gram-positive pathogens [1], including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae, penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). Its orally delivered prodrug is contezolid acefosamil (parent) (MRX-4). Contezolid targets protein synthesis by binding to the V region of the bacterial 23S rRNA.
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References |
1. Li CR, Zhai QQ, Wang XK, Hu XX, Li GQ, Zhang WX, Pang J, Lu X, Yuan H, Gordeev MF et al.. (2014)
In vivo antibacterial activity of MRX-I, a new oxazolidinone. Antimicrob Agents Chemother, 58 (4): 2418-21. [PMID:24395231] |