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Synonyms: RP 57669 | RP-57669 | RP57669 | Synercid® (dalfopristin + quinupristin)
quinupristin is an approved drug (FDA (1999))
Compound class: Synthetic organic
Comment: Quinupristin is a semi-synthetic derivative of streptogramin B. It inhibits the late stage of protein synthesis by binding to the bacterial 50S ribosomal subunit.
1. Gentry DR, McCloskey L, Gwynn MN, Rittenhouse SF, Scangarella N, Shawar R, Holmes DJ. (2008)
Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.
Antimicrob Agents Chemother, 52 (12): 4507-9. [PMID:18838584]