Synonyms: 7alpha-Hydroxy, 3beta-spermidine | MSI-1256F (squalamine lactate)
Compound class:
Synthetic organic
Comment: Squalamine was examined for antibacterial activity against Gram-positive and Gram-negative bacteria [1-2], but development was discontinued at Phase 2.
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References |
1. Djouhri-Bouktab L, Vidal N, Rolain JM, Brunel JM. (2011)
Synthesis of new 3,20-bispolyaminosteroid squalamine analogues and evaluation of their antimicrobial activities. J Med Chem, 54 (20): 7417-21. [PMID:21905738] |
2. Rao MN, Shinnar AE, Noecker LA, Chao TL, Feibush B, Snyder B, Sharkansky I, Sarkahian A, Zhang X, Jones SR et al.. (2000)
Aminosterols from the dogfish shark Squalus acanthias. J Nat Prod, 63 (5): 631-5. [PMID:10843574] |