Synonyms: WCK-5107 | WCK5107
Compound class:
Synthetic organic
Comment: Zidebactam (WCK 5107) is a novel β-lactamase inhibitor [1-2]. It was developed for the treatment of serious infections caused by highly drug-resistant Gram-negative pathogens.
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References |
1. Moya B, Barcelo IM, Bhagwat S, Patel M, Bou G, Papp-Wallace KM, Bonomo RA, Oliver A. (2017)
WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother, 61 (6). [PMID:28289035] |
2. Papp-Wallace KM, Nguyen NQ, Jacobs MR, Bethel CR, Barnes MD, Kumar V, Bajaksouzian S, Rudin SD, Rather PN, Bhavsar S et al.. (2018)
Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem, 61 (9): 4067-4086. [PMID:29627985] |