acetylcysteine   Click here for help

GtoPdb Ligand ID: 10945

Synonyms: Ilube® (eye drops) | N-A-C Sustain® | N-Acetyl-cysteine | N-Acetyl-L-cysteine | NAC | Parvolex®
Approved drug PDB Ligand
acetylcysteine is an approved drug (FDA (1963), UK (1992))
Compound class: Synthetic organic
Comment: Acetylcysteine is a prodrug for L-cysteine synthesis, and L-cysteine is a precursor to the biologic antioxidant glutathione. Hence adminstration of acetylcysteine replenishes glutathione stores.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 105.2
Molecular weight 163.03
XLogP -0.13
No. Lipinski's rules broken 0
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Canonical SMILES SC[C@@H](C(=O)O)NC(=O)C
Isomeric SMILES SC[C@@H](C(=O)O)NC(=O)C
InChI InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
1. Berk M, Malhi GS, Gray LJ, Dean OM. (2013)
The promise of N-acetylcysteine in neuropsychiatry.
Trends Pharmacol Sci, 34 (3): 167-77. [PMID:23369637]
2. Tam J, Nash EF, Ratjen F, Tullis E, Stephenson A. (2013)
Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis.
Cochrane Database Syst Rev, (7): CD007168. [PMID:23852992]