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Compound class: Natural product or derivative
Comment: Altromycin B is a pluramycin-like, anthraquinone antitumour antibiotic that was developed for Gram-negative activity [1-2]. It was isolated from a soil-dwelling actinomycete, AB 1246E-26. As it is a DNA minor groove binder and DNA alkylator it is likely highly toxic.
1. Brill GM, McAlpine JB, Whittern DN, Buko AM. (1990)
Altromycins, novel pluramycin-like antibiotics. II. Isolation and elucidation of structure.
J Antibiot, 43 (3): 229-37. [PMID:2324008]
2. Jackson M, Karwowski JP, Theriault RJ, Hardy DJ, Swanson SJ, Barlow GJ, Tillis PM, McAlpine JB. (1990)
Altromycins, novel pluramycin-like antibiotics. I. Taxonomy of the producing organism, fermentation and antibacterial activity.
J Antibiot, 43 (3): 223-8. [PMID:2324007]