Synonyms: Lysobactin
Compound class:
Natural product
Comment: Katanosins (lysobactins) are antibacterial compounds [2]. They have been isolated from Cytophaga [4] or the Gram-negative bacterium Lysobacter sp [5]. Katanosin B is also known as lysobactin. This can now be chemically synthesised [1,6]. Katanosins target bacterial cell wall biosynthesis [3] and they are potent against problematic Gram-positive hospital pathogens such as staphylococci and enterococci.
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References |
1. Guzman-Martinez A, Lamer R, VanNieuwenhze MS. (2007)
Total synthesis of lysobactin. J Am Chem Soc, 129 (18): 6017-21. [PMID:17432854] |
2. Kato T, Hinoo H, Terui Y, Kikuchi J, Shoji J. (1988)
The structures of katanosins A and B. J Antibiot, 41 (6): 719-25. [PMID:3403365] |
3. Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. (2016)
The Mechanism of Action of Lysobactin. J Am Chem Soc, 138 (1): 100-3. [PMID:26683668] |
4. O'Sullivan J, McCullough JE, Tymiak AA, Kirsch DR, Trejo WH, Principe PA. (1988)
Lysobactin, a novel antibacterial agent produced by Lysobacter sp. I. Taxonomy, isolation and partial characterization. J Antibiot, 41 (12): 1740-4. [PMID:3209465] |
5. Shoji J, Hinoo H, Matsumoto K, Hattori T, Yoshida T, Matsuura S, Kondo E. (1988)
Isolation and characterization of katanosins A and B. J Antibiot, 41 (6): 713-8. [PMID:3403364] |
6. von Nussbaum F, Anlauf S, Benet-Buchholz J, Häbich D, Köbberling J, Musza L, Telser J, Rübsamen-Waigmann H, Brunner NA. (2007)
Structure and total synthesis of lysobactin (katanosin B). Angew Chem Int Ed Engl, 46 (12): 2039-42. [PMID:17211904] |