delpazolid   Click here for help

GtoPdb Ligand ID: 10999

Synonyms: LCB-01,0371 | LCB-01-0371 | LCB01-0371
Compound class: Synthetic organic
Comment: Delpazolid (LCB01-0371) is an oxazolidinone antibacterial [1] that was developed for antitubercular activity.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 68.61
Molecular weight 308.13
XLogP 1.31
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC[C@H]1CN(C(=O)O1)c1ccc(c(c1)F)N1CCN(N=C1)C
Isomeric SMILES OC[C@H]1CN(C(=O)O1)c1ccc(c(c1)F)N1CCN(N=C1)C
InChI InChI=1S/C14H17FN4O3/c1-17-4-5-18(9-16-17)13-3-2-10(6-12(13)15)19-7-11(8-20)22-14(19)21/h2-3,6,9,11,20H,4-5,7-8H2,1H3/t11-/m1/s1
InChI Key QLUWQAFDTNAYPN-LLVKDONJSA-N
References
1. Jeong JW, Jung SJ, Lee HH, Kim YZ, Park TK, Cho YL, Chae SE, Baek SY, Woo SH, Lee HS et al.. (2010)
In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.
Antimicrob Agents Chemother, 54 (12): 5359-62. [PMID:20855730]
2. Kim TS, Choe JH, Kim YJ, Yang CS, Kwon HJ, Jeong J, Kim G, Park DE, Jo EK, Cho YL et al.. (2017)
Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus.
Antimicrob Agents Chemother, 61 (9). [PMID:28674049]