Synonyms: (+)-Sorangicin A
Compound class:
Synthetic organic
Comment: Originally isolated from Sorangium cellulosum, sorangicin A is a macrocyclic lactone carbonic acid with potent activity against Gram-positive bacteria [2].
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References |
1. Campbell EA, Pavlova O, Zenkin N, Leon F, Irschik H, Jansen R, Severinov K, Darst SA. (2005)
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase. EMBO J, 24 (4): 674-82. [PMID:15692574] |
2. Irschik H, Jansen R, Gerth K, Höfle G, Reichenbach H. (1987)
The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria. J Antibiot, 40 (1): 7-13. [PMID:3104268] |