Synonyms: AR-1I9514 | Arbidol®
Compound class:
Synthetic organic
Comment: Umifenovir is an indole-based antiviral drug. It is a viral entry inhibitor [3] and also acts to modulate the host immune response (induces interferon-production, stimulates macrophages phagocytosis).
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References |
1. Hulseberg CE, Fénéant L, Szymańska-de Wijs KM, Kessler NP, Nelson EA, Shoemaker CJ, Schmaljohn CS, Polyak SJ, White JM. (2019)
Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses. J Virol, 93 (8). [PMID:30700611] |
2. Ianevski A, Yao R, Fenstad MH, Biza S, Zusinaite E, Reisberg T, Lysvand H, Løseth K, Landsem VM, Malmring JF et al.. (2020)
Potential Antiviral Options against SARS-CoV-2 Infection. Viruses, 12 (6). [PMID:32545799] |
3. Leneva IA, Russell RJ, Boriskin YS, Hay AJ. (2009)
Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol. Antiviral Res, 81 (2): 132-40. [PMID:19028526] |
4. Pécheur EI, Borisevich V, Halfmann P, Morrey JD, Smee DF, Prichard M, Mire CE, Kawaoka Y, Geisbert TW, Polyak SJ. (2016)
The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses. J Virol, 90 (6): 3086-92. [PMID:26739045] |