osocimab   Click here for help

GtoPdb Ligand ID: 11366

Synonyms: BAY 1213790 | BAY-1213790 | BAY1213790
Compound class: Antibody
Comment: Osocimab (BAY 1213790) is a fully humanized monoclonal antibody that targets activated Factor XI [1]. It is being investigated for clinical prevention of thrombosis [2].
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1. Schaefer M, Buchmueller A, Dittmer F, Stra├čburger J, Wilmen A. (2019)
Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI.
J Mol Biol, 431 (24): 4817-4833. [PMID:31655039]
2. Weitz JI, Bauersachs R, Becker B, Berkowitz SD, Freitas MCS, Lassen MR, Metzig C, Raskob GE. (2020)
Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty: The FOXTROT Randomized Clinical Trial.
JAMA, 323 (2): 130-139. [PMID:31935028]