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Synonyms: example 63 [WO2018045956A1]
Compound class: Synthetic organic
Comment: The chemical structure that was submitted to the WHO for the INN cimpuciclib, matches the stucture of example 63 that is claimed in patent WO2018045956A1 . Data is provided in WO2018045956A1 for example 63's inhibitory activity at CDK4 and CDK6, and for antiproliferative activity against Colo205 colon cancer cells in vitro (IC50 141 nM) and Colo205 xenografts in nude mice.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Liu S, Zhou Y, Wu X, Bao R. (2018)
Benzimidazole compound kinase inhibitor, preparation method therefor and application thereof.
Patent number: WO2018045956A1. Assignee: Jiangsu Haosen Pharmaceutical Group, Shanghai Hansen Biomedical Technology Co.. Priority date: 07/09/2016. Publication date: 15/03/2018.