spexin-1   Click here for help

GtoPdb Ligand ID: 11417

Comment: Spexin-1 has been identified as an agonist of galanin receptors GALR2 and GALR3 [1-2]. It is a cleavage product of the 116 amino acid spexin precursor which is cleaved into two chains: spexin-1 and spexin-2 (FISDQSRRKDLSDRPLPE).
Species: Human
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1. Kim DK, Yun S, Son GH, Hwang JI, Park CR, Kim JI, Kim K, Vaudry H, Seong JY. (2014)
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
Endocrinology, 155 (5): 1864-73. [PMID:24517231]
2. Mirabeau O, Perlas E, Severini C, Audero E, Gascuel O, Possenti R, Birney E, Rosenthal N, Gross C. (2007)
Identification of novel peptide hormones in the human proteome by hidden Markov model screening.
Genome Res, 17 (3): 320-7. [PMID:17284679]