bilastine   Click here for help

GtoPdb Ligand ID: 11579

Synonyms: Bilaxten® | Ilaxten®
Approved drug
bilastine is an approved drug (UK (2010))
Compound class: Synthetic organic
Comment: Bilastine is a non-sedating histamine H1 receptor antagonist/inverse agonist [2-3]. A repurposing screen of small molecule drugs discovered that bilastine inhibits SARS-CoV-2 Mpro activity by around 20% (see CHEMBL4495564).
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2D Structure
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Canonical SMILES CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C
Isomeric SMILES CCOCCn1c(nc2c1cccc2)C1CCN(CC1)CCc1ccc(cc1)C(C(=O)O)(C)C
InChI InChI=1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33)
1. Corc√≥stegui R, Labeaga L, Inner√°rity A, Berisa A, Orjales A. (2005)
Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist: receptor selectivity and in vitro antihistaminic activity.
Drugs R D, 6 (6): 371-84. [PMID:16274260]
2. Sharma S, Hatware K, Bhadane P, Patil K. (2021)
Chemistry, Pharmacokinetics, Pharmacodynamics and Analytical Methods of Bilastine, a Histamine H1 Receptor Antagonist: An Update.
Mini Rev Med Chem, 21 (20): 3183-3190. [PMID:33992058]
3. Wolthers OD. (2013)
Bilastine: a new nonsedating oral H1 antihistamine for treatment of allergic rhinoconjunctivitis and urticaria.
Biomed Res Int, 2013: 626837. [PMID:23956994]