Honokiol   Click here for help

GtoPdb Ligand ID: 11610

PDB Ligand
Compound class: Natural product
Comment: Honokiol is a lignan that is produced by Magnolia trees that has been widely used in traditional medicine in East Asia. It has been described as having many pharmacological effects [2-5], with activities at a number of protein targets [1]. Honokiol's anti-cancer potential has been extensively investigated [3].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

Honokiol is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 40.46
Molecular weight 266.13
XLogP 5.53
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)O)O
Isomeric SMILES C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)O)O
InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChI Key FVYXIJYOAGAUQK-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Banik K, Ranaware AM, Deshpande V, Nalawade SP, Padmavathi G, Bordoloi D, Sailo BL, Shanmugam MK, Fan L, Arfuso F et al.. (2019)
Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.
Pharmacol Res, 144: 192-209. [PMID:31002949]
2. Chen C, Zhang QW, Ye Y, Lin LG. (2021)
Honokiol: A naturally occurring lignan with pleiotropic bioactivities.
Chin J Nat Med, 19 (7): 481-490. DOI: 10.1016/S1875-5364(21)60047-X [PMID:34247771]
3. Mottaghi S, Abbaszadeh H. (2022)
Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review.
Nutr Cancer, 74 (3): 761-778. [PMID:34047218]
4. Ong CP, Lee WL, Tang YQ, Yap WH. (2019)
Honokiol: A Review of Its Anticancer Potential and Mechanisms.
Cancers (Basel), 12 (1). [PMID:31877856]
5. Pan J, Lee Y, Wang Y, You M. (2016)
Honokiol targets mitochondria to halt cancer progression and metastasis.
Mol Nutr Food Res, 60 (6): 1383-95. [PMID:27276215]
6. Schühly W, Hüfner A, Pferschy-Wenzig EM, Prettner E, Adams M, Bodensieck A, Kunert O, Oluwemimo A, Haslinger E, Bauer R. (2009)
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
Bioorg Med Chem, 17 (13): 4459-65. [PMID:19481465]